Endocrine Abstracts

Background: Significant prevalence of hypertension in the world’s population and its consequences tend to an intensive search for pathogenesis and etiology of this disease. Epidemic of hypertension is accompanied by an epidemic of adrenal incidentaloma and grows in direct proportion to patients age. Polymorphism of aldosterone synthase (CYP11B2) in -344th region of promoter seems to have much in common with hypertension and adrenal incidentaloma.Aim...

Introduction: Nowadays is believed that primary aldosteronism (PA) is the most frequent cause of secondary hypertension and reaches 10% of whole hypertensive population. The activity of the mineralocorticoid hormone may be change by polymorphism of aldosterone synthase gene (CYP11B2) e.g. in promoter -344T/C region. Aim of this study was to find differences in baseline plasma aldosterone concentration (PAC), plasma renin activity (PRA), aldosterone – renin ratio (ARR) and...

Two female patients aged 44 (PtA) and 68 years old (PtB) with non-toxic nodular goitre for more than 10 years were treated with radioiodine therapy. High resolution ultrasonography show enlarged thyroid glands 50 ml, with two nodules in left and right lobe in PtA and 58 ml with one nodule in the left lobe in PtB. Serum TSH, fT4 and fT3 were in normal ranges. Malignancy was ruled out by ultrasound-guided fine-needle aspiration biopsy. In PtA thyroid radioi...

It was shown recently that orbital fibroblasts express intensively CD40 and its ligation stimulates proinflammatory cytokines, glicosoaminoglycans and PGE2 production. CD40/CD154 interaction in the pathogenesis of Graves’ orbitopathy (GO) is suggested an important pathway of T cells induced fibroblast activation and proliferation.Aim: To assess the role of CD40/CD154 interaction in GO pathogenesis and to estimate usefulness of soluble CD4...

Background and aims: Interleukin-12 (IL-12) is a pro inflammatory cytokine, which was suggested to play a key role in the pathogenesis of Th1-cell-mediated autoimmune diseases. The aim of our study was to estimate the association of 1188A/C polymorphism of IL12B gene with the predisposition to Graves’ disease (GD) in Polish population.Materials and methods: The study was performed in the group consisting of 245 individuals with GD sequentially recru...

Most of the patients with the benign cold nodule refuse surgical operation. Radioiodine therapy (RIT) is the choice for these patients. The aim of our study was to evaluate the efficacy of radioiodine therapy to reduce thyroid volume in patients with cold nodule by the use of two doses of radioiodine.Methods: We treated 40 patients with non-toxic nodular goitre with large cold nodule, aged 18 and 48 years; initial 24 h radioiodine uptake (RAIU) was range...

Introduction: Treatment of Graves orbitopathy (GO) is one of the most difficult problems in clinical endocrinology. Objective: To establish the efficacy of the regime used in the treatment of GO and to analyze methods used to determine treatment effectiveness.Material: The study involved 30 patients with moderate to severe GO (according to the classification of EUGOGO) being in the active phase of GO.Method: ...

Aim: The aim of our study was to evaluate the influence of recombinant human thyroid-stimulating hormone (rhTSH) on the efficacy of radioiodine therapy in patients with non toxic nodular goitre with low RAIU.Materials and methods: The study was performed on 50 patients with non toxic nodular goitre (36 females and 14 males, aged 34–75 years) referred for radioiodine therapy. All patients had low RAIU (8–16%), 24 h after a diagnostic dose of I-1...

Aims: We assessed periodontal status in patients with type 1 diabetes and healthy individuals in relation to their glycemic control, smoking, and inflammatory biomarkers.Methods: Periodontal status was examined in 107 patients with type 1 diabetes and 40 controls, using oral hygiene index (OHI), community periodontal index (CPI) and teeth number. CPI values of 0–2 and 3–4 were classified as non-periodontitis and periodontitis respectively. Bloo...

Interleukin-6 (IL-6) has been shown to be involved in the pathogenesis of several bone diseases characterized by an imbalance between bone resorption and formation. Lately we have published our data suggesting an important role of IL-6 in thyrotoxicosis-related osteoporosis in mice (Horm Metab Res 2007 39 1–5).Aim: The aim of the study was to estimate serum markers of bone turnover: osteoclast-derived tartrate-resistant acid phosphatas...